Brief introduction of (2,2-Dichlorocyclopropyl)benzene CAS 2415-80-7

Chemical name: (2,2-Dichlorocyclopropyl)benzene

CAS No.：2415-80-7

Synonyms: 1,1-dichloro-2-phenyl cyclopropanen

Molecular Formula: C9H8Cl2

Molecuar Weight: 187.07

EINECS: 219-326-1

Properties of (2,2-Dichlorocyclopropyl)benzene CAS 2415-80-7

(2,2-Dichlorocyclopropyl)benzene is made by Into a 250 ml four-necked flask were added 30 g of styrene, 30 ml of dichloromethane, 43.5 g of chloroform, and 1.2 g of TEBA (benzyl triethyl ammonium chloride). The temperature was raised to reflux, lye (28.5gNaOH+28.5ml water) was added dropwise, and the reaction was refluxed for 8 hours. Cool to room temperature, add 60Chemicalbookml water, stir for 10 minutes, let stand to separate the layers, extract the aqueous layer with petroleum ether, combine the organic layers, dry with anhydrous sodium sulfate, filter, and distill the filtrate with oil pump high vacuum distillation, slowly warm up to the distillate After stabilization, distill at a temperature of about 95-100°C to obtain a colorless liquid. Yield: 88.6%; HPLC purity: 99.2%.

Specification of (2,2-Dichlorocyclopropyl)benzene CAS 2415-80-7

Application of (2,2-Dichlorocyclopropyl)benzene CAS 2415-80-7

(2,2-Dichlorocyclopropyl)benzene is an organic intermediate, which can be prepared in one step from styrene. (2,2-Dichlorocyclopropyl)benzene can be used to prepare ciprofibrate. (2,2-Dichlorocyclopropyl)benzene was obtained by Friedel-Crafts acylation, Baeyer-Villiger oxidation, alcohol Chemicalbook hydrolysis, alkylation, and hydrolysis to obtain ciprofibrate. Ciprofibrate is a phenoxyacetic acid hypolipidemic drug with the chemical name 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionic acid, developed by Synthelabo, France. It is clinically used for type II and type IV hyperlipoproteinemia that cannot be controlled by diet therapy.

Packing, Delivery and Storage of (2,2-Dichlorocyclopropyl)benzene CAS 2415-80-7

Package: 200kg /drum, or as per customer request.

Storage conditions: store in a cool and dry place.