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Mecobalamin (CSA No 13422-55-4), is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal-alkyl bonds. Nickel-methyl intermediates have been proposed for the final step of methanogenesis.
Specification
Appearance dark red srystals or crystallline powder
Related substances(HPLC) less than 2.0%
Individual impurities less than 0.5%
Water(K.F) less than 12.0%
Assay(on anhydrous basis) more than 98.0%
Residual solvent(GC)
Total plant count less than 1000cfu/g
Application
Methylcobalamin is equivalent physiologically to vitamin B12 and can be used to prevent or treat pathology arising from a lack of vitamin B12 (vitamin B12 deficiency), such as pernicious anemia.
Methylcobalamin is also used in the treatment of peripheral neuropathy, diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis.
Methylcobalamin that is ingested is not used directly as a cofactor, but is first converted by MMACHC into cob(II)alamin. Cob(II)alamin is then later converted into the other 2 forms, adenosylcobalamin and methylcobalamin for use as cofactors. That is, methylcobalamin is first dealkylated and then regenerated.
Packing&Storage
100 g/tin.
Stored in day and cool place and keep away from strong light and heat.
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